| RRC ID |
41594
|
| Author |
Rumi MA, Sato H, Ishihara S, Ortega C, Kadowaki Y, Kinoshita Y.
|
| Title |
Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands.
|
| Journal |
J Lab Clin Med
|
| Abstract |
The growth of human cancer cells expressing peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been reported to be inhibited by PPAR-gamma ligands. In esophageal squamous-cell carcinoma cell lines T.T, T.Tn, and EC-GI-10, we detected expression of PPAR-gamma and investigated the effects of PPAR-gamma ligands on these cell lines in vitro with the use of troglitazone, pioglitazone, and 15d-PGJ2. Marked growth inhibition by the PPAR-gamma ligands was observed in all cases. The growth-inhibitory effect was evidenced by a dose-dependent inhibition of deoxyribonucleic acid synthesis and was associated with altered cell-cycle progression manifesting G1 arrest. Cell-cycle arrest in T.Tn cells induced by troglitazone could be correlated with an increased level of cyclin-dependent kinase inhibitor p27(Kip1), p21(Cip1/Waf1), and p18(Ink4c). Moreover, troglitazone treatment increased the expression of interleukin-1 alpha, a multifunctional cytokine implicated in antitumor immunity. These findings suggest that troglitazone and other PPAR-gamma ligands have adjuvant or neoadjuvant therapeutic potentials in esophageal cancer.
|
| Volume |
140(1)
|
| Pages |
17-26
|
| Published |
2002-7-1
|
| DOI |
10.1067/mlc.2002.125055
|
| PII |
S0022214302000136
|
| PMID |
12080324
|
| MeSH |
Carcinoma, Squamous Cell / pathology*
Cell Cycle / drug effects
Cell Division / physiology
Chromans / pharmacology*
DNA Replication / drug effects
Esophageal Neoplasms / pathology*
Gene Expression Regulation, Neoplastic* / drug effects
Humans
Ligands
RNA, Messenger / genetics
Receptors, Cytoplasmic and Nuclear / genetics
Receptors, Cytoplasmic and Nuclear / physiology*
Thiazoles / pharmacology*
Thiazolidinediones*
Transcription Factors / genetics
Transcription Factors / physiology*
Transcription, Genetic*
Troglitazone
Tumor Cells, Cultured
|
| Times Cited |
31
|
|
WOS Category
|
MEDICAL LABORATORY TECHNOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Human and Animal Cells |
MKN-45(RCB1001)
KG-1(RCB1166) |
