| RRC ID |
41607
|
| 著者 |
Kimura Y.
|
| タイトル |
Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice.
|
| ジャーナル |
J Nutr
|
| Abstract |
I examined the effects of carp oil, oleic acid, linoleic acid and linolenic acid on tumor growth and metastasis to the liver in mice implanted intrasplenically with highly metastatic Lewis lung carcinoma (LLC) tumors. Carp oil (0.1 or 0.2 mL per mouse) significantly reduced tumor growth and metastasis to the liver. Carp oil at 100 or 1000 mg/L inhibited the DNA synthesis in LLC cells, the capillary-like tube formation of human dermal microvascular endothelial cells (HMVEC) at 1000 mg/L and the adherence of LLC cells to HMVEC at 10 to 1000 mg/L (in vitro). Carp oil (0.2 mL per mouse) inhibited the angiogenesis induced by Matrigel supplemented with vascular endothelial growth factor (VEGF) and heparin (in vivo). Antitumor and antimetastatic actions of carp oil might be partly attributable to the inhibition of DNA synthesis in LLC cells and angiogenesis through the inhibition of the adherence of LLC cells to the microvascular endothelium. Oleic acid (0.1 or 0.2 mL per mouse) significantly inhibited the metastasis to the liver, but it had no effect on the primary solid-tumor growth. Oleic acid inhibited the angiogenesis in both in vitro and in vivo models. Oleic acid at 1000 micromol/L inhibited the DNA synthesis in LLC cells but did not affect the DNA synthesis in HMVEC. These inhibitory actions of oleic acid may be attributable to the inhibition of angiogenesis induced by the tumor. Linoleic acid and linolenic acid had no effect on tumor growth or metastasis to the liver.
|
| 巻・号 |
132(7)
|
| ページ |
2069-75
|
| 公開日 |
2002-7-1
|
| DOI |
10.1093/jn/132.7.2069
|
| PMID |
12097695
|
| MeSH |
Animals
Biocompatible Materials / pharmacology
Blood Cell Count
Body Weight / drug effects
Carcinoma, Lewis Lung / blood supply
Carcinoma, Lewis Lung / pathology*
Carcinoma, Lewis Lung / secondary
Carps*
Collagen / pharmacology
DNA / biosynthesis
Drug Combinations
Energy Intake / drug effects
Fish Oils / pharmacology*
Humans
Laminin / pharmacology
Linoleic Acid / pharmacology
Lung Neoplasms / blood supply
Lung Neoplasms / pathology*
Mice
Mice, Inbred C57BL
Neoplasm Metastasis / prevention & control
Neovascularization, Pathologic / prevention & control
Oleic Acid / pharmacology*
Organ Size / drug effects
Proteoglycans / pharmacology
Tumor Cells, Cultured
alpha-Linolenic Acid / pharmacology
|
| IF |
4.281
|
| 引用数 |
36
|
|
WOS 分野
|
NUTRITION & DIETETICS
|
| リソース情報 |
| ヒト・動物細胞 |
|
