論文 - 詳細
| RRC ID | 41607 |
|---|---|
| 著者 | Kimura Y. |
| タイトル | Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. |
| ジャーナル | J Nutr |
| Abstract |
I examined the effects of carp oil, oleic acid, linoleic acid and linolenic acid on tumor growth and metastasis to the liver in mice implanted intrasplenically with highly metastatic Lewis lung carcinoma (LLC) tumors. Carp oil (0.1 or 0.2 mL per mouse) significantly reduced tumor growth and metastasis to the liver. Carp oil at 100 or 1000 mg/L inhibited the DNA synthesis in LLC cells, the capillary-like tube formation of human dermal microvascular endothelial cells (HMVEC) at 1000 mg/L and the adherence of LLC cells to HMVEC at 10 to 1000 mg/L (in vitro). Carp oil (0.2 mL per mouse) inhibited the angiogenesis induced by Matrigel supplemented with vascular endothelial growth factor (VEGF) and heparin (in vivo). Antitumor and antimetastatic actions of carp oil might be partly attributable to the inhibition of DNA synthesis in LLC cells and angiogenesis through the inhibition of the adherence of LLC cells to the microvascular endothelium. Oleic acid (0.1 or 0.2 mL per mouse) significantly inhibited the metastasis to the liver, but it had no effect on the primary solid-tumor growth. Oleic acid inhibited the angiogenesis in both in vitro and in vivo models. Oleic acid at 1000 micromol/L inhibited the DNA synthesis in LLC cells but did not affect the DNA synthesis in HMVEC. These inhibitory actions of oleic acid may be attributable to the inhibition of angiogenesis induced by the tumor. Linoleic acid and linolenic acid had no effect on tumor growth or metastasis to the liver. |
| 巻・号 | 132(7) |
| ページ | 2069-75 |
| 公開日 | 2002-7-1 |
| DOI | 10.1093/jn/132.7.2069 |
| PMID | 12097695 |
| MeSH | Animals Biocompatible Materials / pharmacology Blood Cell Count Body Weight / drug effects Carcinoma, Lewis Lung / blood supply Carcinoma, Lewis Lung / pathology* Carcinoma, Lewis Lung / secondary Carps* Collagen / pharmacology DNA / biosynthesis Drug Combinations Energy Intake / drug effects Fish Oils / pharmacology* Humans Laminin / pharmacology Linoleic Acid / pharmacology Lung Neoplasms / blood supply Lung Neoplasms / pathology* Mice Mice, Inbred C57BL Neoplasm Metastasis / prevention & control Neovascularization, Pathologic / prevention & control Oleic Acid / pharmacology* Organ Size / drug effects Proteoglycans / pharmacology Tumor Cells, Cultured alpha-Linolenic Acid / pharmacology |
| IF | 4.281 |
| 引用数 | 36 |
| WOS 分野 | NUTRITION & DIETETICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |