Reference - Detail
| RRC ID | 41624 |
|---|---|
| Author | Nonaka M, Ikeda H, Inokuchi T. |
| Title | Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro. |
| Journal | Cancer Lett |
| Abstract |
We investigated the cytotoxic and apoptotic effects of a combination of photodynamic therapy (PDT) and cisplatin (CDDP) on L5178Y (LY) cells. Treatment with PDT by photofrin((R)) (5 microg/ml) alone or with CDDP (20 microg/ml) alone killed 41.5+/-8.5% or 42.9+/-6.5% of LY cells, respectively, while a combination of these two treatments killed 99.7+/-0.6%. Apoptotic cell death after combination treatment was also revealed to be 49.6+/-7.8% compared to 12.4+/-3.4% after PDT alone, and 18.8+/-2.6% after CDDP. This study demonstrated that combined treatment of PDT and CDDP results in enhanced apoptotic cell death as well as a cytotoxic effect on LY cells. |
| Volume | 184(2) |
| Pages | 171-8 |
| Published | 2002-10-28 |
| DOI | 10.1016/s0304-3835(02)00208-2 |
| PII | S0304383502002082 |
| PMID | 12127689 |
| MeSH | Antineoplastic Agents / toxicity* Apoptosis / drug effects* Cell Survival / drug effects* Cisplatin / toxicity* Dihematoporphyrin Ether / toxicity* Humans Photochemotherapy* Tumor Cells, Cultured |
| IF | 7.36 |
| Times Cited | 30 |
| WOS Category | ONCOLOGY |
| Resource | |
| Human and Animal Cells | L5178Y(RCB0135) |