| RRC ID |
41655
|
| 著者 |
Shin VY, Liu ES, Koo MW, Luo JC, So WH, Cho CH.
|
| タイトル |
Nicotine suppresses gastric wound repair via the inhibition of polyamine and K(+) channel expression.
|
| ジャーナル |
Eur J Pharmacol
|
| Abstract |
Nicotine is one of the most representative components in cigarette smoke leading to gastric ulceration. Both ornithine decarboxylase and potassium ion (K(+)) channels are essential for cell growth and wound repair. The aim of the present study is to elucidate the causative relationship of these two factors during wound healing and the influence of nicotine on this healing process in rat gastric mucosal epithelial cells (RGM-1). Nicotine markedly inhibited cell migration and proliferation in RGM-1 cells. The latter effect was significantly antagonized by a nicotinic receptor blocker, mecamylamine. Nicotine also suppressed ornithine decarboxylase activity significantly. Our data showed that inhibition of cell proliferation and ornithine decarboxylase activity by nicotine was accompanied with a reduction in K(+) channel protein expression, all of which were significantly alleviated by spermidine pretreatment. These results suggested that there was a cause/effect link between ornithine decarboxylase and K(+) channel on wound repair. Nicotine in cigarette smoke inhibited this healing process and delayed wound repair in gastric epithelial cells.
|
| 巻・号 |
444(1-2)
|
| ページ |
115-21
|
| 公開日 |
2002-5-24
|
| DOI |
10.1016/s0014-2999(02)01610-2
|
| PII |
S0014299902016102
|
| PMID |
12191590
|
| MeSH |
Animals
Cell Movement / drug effects
Gastric Mucosa / drug effects
Nicotine / toxicity*
Ornithine Decarboxylase / pharmacology
Ornithine Decarboxylase / physiology*
Polyamines / antagonists & inhibitors*
Potassium Channels / drug effects*
Rats
Wound Healing / drug effects*
|
| IF |
3.263
|
| 引用数 |
26
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
RGM1(RCB0876) |
