| RRC ID |
41707
|
| Author |
Morita H, He F, Fuse T, Ouwehand AC, Hashimoto H, Hosoda M, Mizumachi K, Kurisaki J.
|
| Title |
Cytokine production by the murine macrophage cell line J774.1 after exposure to lactobacilli.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 to secrete cytokines. Some of the bacteria tested induce the production of interleukin(IL) 6, IL-12, and tumor necrosis factor a (TNF-alpha) by J774.1 cells. Seven strains also induced the production of IL-10. However, no IL-1beta was produced. Lactobacillus acidophilus TMC 0356 significantly induced the production of more IL-6, IL-10, IL-12, and TNF-alpha than the other bacteria tested (p < 0.0001; ANOVA). These results suggest that lactobacilli can activate macrophages to secrete both inflammatory and anti-inflammatory cytokines. Selected strains might be used to bring about pro or antiinflammatory immune reactions.
|
| Volume |
66(9)
|
| Pages |
1963-6
|
| Published |
2002-9-1
|
| DOI |
10.1271/bbb.66.1963
|
| PMID |
12400700
|
| MeSH |
Animals
Cell Line
Cytokines / biosynthesis*
Lactobacillus / physiology*
Macrophage Activation
Macrophages / immunology
Macrophages / metabolism*
Macrophages / microbiology*
Mice
|
| IF |
1.516
|
| Times Cited |
88
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
J774.1(RCB0434) |
