論文 - 詳細
| RRC ID | 41719 |
|---|---|
| 著者 | Ogasawara M, Matsunaga T, Takahashi S, Saiki I, Suzuki H. |
| タイトル | Anti-invasive and metastatic activities of evodiamine. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
We have recently reported that evodiamine can suppress in vitro invasion and lung metastasis by colon 26-L5 carcinoma cells. To extend our study, we examine here the anti-invasive and metastatic effects of evodiamine on Lewis lung carcinoma (LLC) and B16-F10 melanoma in addition to colon 26-L5 carcinoma. Critical structures of evodiamine for the activities were also evaluated by comparison with compounds possessing structures similar to that of evodiamine. Evodiamine concentration-dependently inhibited the invasion of B16-F10, LLC and colon 26-L5 cells with IC(50) values of 2.4 micro M, 4.8 micro M and 3.7 micro M, respectively. Pre-treatment of colon 26-L5 cells with evodiamine before inoculation into mice caused significant suppression of the liver metastasis as well as the lung metastasis. Lung metastasis by LLC is also inhibited significantly by pre-exposure to evodiamine. When the anti-migratory activity of evodiamine was compared with that of evodiamine-like compounds, rutaecarpine lacking a methyl group at N-14 and a hydrogen at C-13 b exhibited much less effect than evodiamine. In addition, reserpine, having beta-configurated hydrogen at C-13 b, inhibited tumor cell migration more potently than yohimbine, having alpha-configurated hydrogen at the same position. These results suggest that evodiamine may be useful as a leading compound for agents in tumor metastasis therapy. Also, the presence of a methyl group at N-14 and the configuration of hydrogen at C-13 b may be responsible for the inhibitory activities of evodiamine. |
| 巻・号 | 25(11) |
| ページ | 1491-3 |
| 公開日 | 2002-11-1 |
| DOI | 10.1248/bpb.25.1491 |
| PMID | 12419968 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / pharmacology Antineoplastic Agents, Phytogenic / therapeutic use* Carcinoma, Lewis Lung / drug therapy Cell Movement / drug effects Cell Movement / physiology Colonic Neoplasms / drug therapy Evodia / chemistry* Female Melanoma, Experimental / drug therapy Mice Mice, Inbred BALB C Plant Extracts / chemistry Plant Extracts / pharmacology Plant Extracts / therapeutic use* Quinazolines / chemistry Quinazolines / pharmacology Quinazolines / therapeutic use* |
| IF | 1.863 |
| 引用数 | 65 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |