RRC ID 41735
著者 Komatsu W, Miura Y, Yagasaki K.
タイトル Induction of tumor necrosis factor production and antitumor effect by cabbage extract.
ジャーナル Nutr Cancer
Abstract The effect of cabbage extract on the production of tumor necrosis factor and its implication in the antitumor effect were examined in vitro and in vivo. Cabbage extract stimulated the production of tumor necrosis factor by rat spleen cells and showed cytotoxic activity in a rat ascites hepatoma cell line (AH109A) when hepatoma cells were cultured with cabbage-stimulated spleen cells. When the extract was adminstered orally to AH109A-bearing rats in combination with lipopolysaccharide injection, the hepatoma weights were reduced to one-half of the vehicle control. The cytotoxic activity of tumor-infiltrating macrophages was induced by simultaneous treatment with cabbage extract and lipopolysaccharide. These results indicate that cabbage extract contains macrophage-stimulating component(s) and can implement the antitumor effect by stimulating the cytotoxicity of tumor-infiltrating macrophages.
巻・号 43(1)
ページ 82-9
公開日 2002-1-1
DOI 10.1207/S15327914NC431_10
PMID 12467139
MeSH Animals Antineoplastic Agents / metabolism* Brassica* Carcinoma, Hepatocellular / chemically induced Carcinoma, Hepatocellular / metabolism* Disease Models, Animal Dose-Response Relationship, Drug Liver Neoplasms, Experimental / chemically induced Liver Neoplasms, Experimental / metabolism* Macrophages / metabolism Male Phytotherapy* Plant Extracts / pharmacology* Rats Spleen / metabolism Time Factors Tumor Cells, Cultured / transplantation Tumor Necrosis Factor-alpha / biosynthesis*
IF 2.363
引用数 6
WOS 分野 NUTRITION & DIETETICS ONCOLOGY
リソース情報
ヒト・動物細胞 L929