RRC ID 41767
Author He F, Morita H, Ouwehand AC, Hosoda M, Hiramatsu M, Kurisaki J, Isolauri E, Benno Y, Salminen S.
Title Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains.
Journal Microbiol. Immunol.
Abstract To characterize the ability of bifidobacteria to affect the production of macrophage-derived cytokines, a murine macrophage-like cell line, J774.1, was cultured in the presence of 27 strains of heat-inactivated bifidobacteria. Bifidobacterium adolescentis and B. longum, known as adult-type bifidobacteria, induced significantly more pro-inflammatory cytokine secretion, IL-12 and TNF-alpha, by J774.1 cells, than did the infant-type bifidobacteria, B. bifidum, B. breve, and B. infantis (P<0.01). In contrast, B. adolescentis did not stimulate the production of anti-inflammatory IL-10 from J774.1 cells as the other tested bacteria did. The results suggest that the adult-type bifidobacteria, especially B. adolescentis, may be more potent to amplify but less able to down-regulate the inflammatory response.
Volume 46(11)
Pages 781-5
Published 2002
DOI 10.1111/j.1348-0421.2002.tb02765.x
PMID 12516776
MeSH Adult Animals Bifidobacterium / immunology* Cell Line Cytokines / metabolism* Female Humans Infant, Newborn Inflammation / immunology* Macrophages / immunology* Macrophages / microbiology Mice Mice, Inbred BALB C Species Specificity
IF 1.335
Times Cited 66
Human and Animal Cells