論文 - 詳細
| RRC ID | 41767 |
|---|---|
| 著者 | He F, Morita H, Ouwehand AC, Hosoda M, Hiramatsu M, Kurisaki J, Isolauri E, Benno Y, Salminen S. |
| タイトル | Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains. |
| ジャーナル | Microbiol Immunol |
| Abstract |
To characterize the ability of bifidobacteria to affect the production of macrophage-derived cytokines, a murine macrophage-like cell line, J774.1, was cultured in the presence of 27 strains of heat-inactivated bifidobacteria. Bifidobacterium adolescentis and B. longum, known as adult-type bifidobacteria, induced significantly more pro-inflammatory cytokine secretion, IL-12 and TNF-alpha, by J774.1 cells, than did the infant-type bifidobacteria, B. bifidum, B. breve, and B. infantis (P<0.01). In contrast, B. adolescentis did not stimulate the production of anti-inflammatory IL-10 from J774.1 cells as the other tested bacteria did. The results suggest that the adult-type bifidobacteria, especially B. adolescentis, may be more potent to amplify but less able to down-regulate the inflammatory response. |
| 巻・号 | 46(11) |
| ページ | 781-5 |
| 公開日 | 2002-1-1 |
| DOI | 10.1111/j.1348-0421.2002.tb02765.x |
| PMID | 12516776 |
| MeSH | Adult Animals Bifidobacterium / immunology* Cell Line Cytokines / metabolism* Female Humans Infant, Newborn Inflammation / immunology* Macrophages / immunology* Macrophages / microbiology Mice Mice, Inbred BALB C Species Specificity |
| IF | 1.566 |
| 引用数 | 74 |
| WOS 分野 | MICROBIOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |