論文 - 詳細
| RRC ID | 41770 |
|---|---|
| 著者 | Yamada K, Hamada A, Kisa F, Miyamoto T, Higuchi R. |
| タイトル | Constituents of Holothuroidea, 13. Structure of neuritogenic active ganglioside molecular species from the sea cucumber Stichopus chloronotus. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Three ganglioside molecular species, SCG-1, SCG-2, and SCG-3, were obtained from the lipid fraction of the chloroform-methanol extract of the sea cucumber Stichopus chloronotus. On the basis of chemical and spectroscopic evidence, the structures of these gangliosides have been determined to be 1-O-[(N-glycolyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (SCG-1), 1-O-[8-O-sulfo(major)-(N-acetyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (SCG-2), and 1-O-[alpha-L-fucopyranosyl-(1-->11)-(N-glycolyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (SCG-3). The ceramide moieties were composed of heterogeneous long-chain base and fatty acid units. SCG-3 is the first type of ganglioside containing a fucopyranose in the sialosyl trisaccharide moiety. Moreover, these three gangliosides exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor. |
| 巻・号 | 51(1) |
| ページ | 46-52 |
| 公開日 | 2003-1-1 |
| DOI | 10.1248/cpb.51.46 |
| PMID | 12520127 |
| MeSH | Animals Carbohydrate Sequence Gangliosides / chemistry* Gangliosides / isolation & purification Gangliosides / pharmacology Molecular Sequence Data Neurites / drug effects* Neurites / physiology PC12 Cells Rats Sea Cucumbers / chemistry* |
| IF | 1.416 |
| 引用数 | 26 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Policy sources |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |