論文 - 詳細
| RRC ID | 41773 |
|---|---|
| 著者 | Nagahama M, Morimitsu S, Kihara A, Akita M, Setsu K, Sakurai J. |
| タイトル | Involvement of tachykinin receptors in Clostridium perfringens beta-toxin-induced plasma extravasation. |
| ジャーナル | Br J Pharmacol |
| Abstract |
1 Clostridium perfringens beta-toxin causes dermonecrosis and oedema in the dorsal skin of animals. In the present study, we investigated the mechanisms of oedema induced by the toxin. 2 The toxin induced plasma extravasation in the dorsal skin of Balb/c mice. 3 The extravasation was significantly inhibited by diphenhydramine, a histamine 1 receptor antagonist. However, the toxin did not cause the release of histamine from mouse mastocytoma cells. 4 Tachykinin NK(1) receptor antagonists, [D-Pro(2), D-Trp(7,9)]-SP, [D-Pro(4), D-Trp(7,9)]-SP and spantide, inhibited the toxin-induced leakage in a dose-dependent manner. Furthermore, the non-peptide tachykinin NK(1) receptor antagonist, SR140333, markedly inhibited the toxin-induced leakage. 5 The leakage induced by the toxin was markedly reduced in capsaicin-pretreated mouse skin but the leakage was not affected by systemic pretreatment with a calcitonin gene-related peptide receptor antagonist (CGRP(8-37)). 6 The toxin-induced leakage was significantly inhibited by the N-type Ca(2+) channel blocker, omega-conotoxin MVIIA, and the bradykinin B(2) receptor antagonist, HOE140 (D-Arg-[Hyp(3), Thi(5), D-Tic(7), Oic(8)]-bradykinin), but was not affected by the selective L-type Ca(2+) channel blocker, verapamil, the P-type Ca(2+) channel blocker, omega-agatoxin IVA, tetrodotoxin (TTX), the TTX-resistant Na(+) channel blocker, carbamazepine, or the sensory nerve conduction blocker, lignocaine. 7 These results suggest that plasma extravasation induced by beta-toxin in mouse skin is mediated via a mechanism involving tachykinin NK(1) receptors. |
| 巻・号 | 138(1) |
| ページ | 23-30 |
| 公開日 | 2003-1-1 |
| DOI | 10.1038/sj.bjp.0705022 |
| PII | 0705022 |
| PMID | 12522069 |
| PMC | PMC1573648 |
| MeSH | Animals Bacterial Toxins / pharmacology* Edema / blood* Edema / chemically induced Edema / pathology Male Mice Mice, Inbred BALB C Receptors, Tachykinin / antagonists & inhibitors Receptors, Tachykinin / metabolism* Skin / drug effects* Skin / metabolism Skin / pathology Tumor Cells, Cultured |
| IF | 7.73 |
| 引用数 | 23 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | P-815(RCB1167) |