論文 - 詳細
| RRC ID | 41782 |
|---|---|
| 著者 | Doi K, Horiuchi T, Uchinami M, Tabo T, Kimura N, Yokomachi J, Yoshida M, Tanaka K. |
| タイトル | Neutrophil elastase inhibitor reduces hepatic metastases induced by ischaemia-reperfusion in rats. |
| ジャーナル | Eur J Surg |
| Abstract |
OBJECTIVE:To investigate the possibility in rats that ONO-5046 Na, a new recombinant inhibitor of neutrophil elastase, can reduce hepatic metastases induced by ischaemia-reperfusion. DESIGN:Laboratory experimental study. SETTING:Research laboratory, Japan. SUBJECTS:Male Fischer rats. INTERVENTIONS:Rats underwent 60 min of 70% partial hepatic ischaemia, after which rat colon adenocarcinoma cells (RCN-H4) were injected into the spleen. The animals were divided into two test groups and a control group. One group was given ONO-5046 Na intravenously at 10 mg/kg/hour. A second group was given a saline solution for the same period, while the controls were not made ischaemic. MAIN OUTCOME MEASURES:Three weeks after inoculation, the number of tumour nodules on the liver surface was counted. The anti-cancer effect of ONO-5046 Na was measured by monotetrazolium assay. RESULTS:Hepatic ischaemia-reperfusion increased the number of liver metastases of RCN-H4 in both clamped and unclamped hepatic lobes. ONO-5046 Na significantly inhibited this in unclamped lobes, but had no anti-cancer effect. CONCLUSION:Neutrophil elastase may have an important role in increasing haematogenous liver metastases by ischaemia-reperfusion, particularly in unclamped lobes. |
| 巻・号 | 168(8-9) |
| ページ | 507-10 |
| 公開日 | 2002-1-1 |
| DOI | 10.1080/110241502321116541 |
| PMID | 12549694 |
| MeSH | Animals Glycine / analogs & derivatives* Glycine / pharmacology* Liver Circulation / physiology Liver Neoplasms, Experimental / prevention & control* Liver Neoplasms, Experimental / secondary* Male Rats Rats, Inbred F344 Reperfusion Injury / complications* Serpins / pharmacology* Sulfonamides / pharmacology* |
| 引用数 | 21 |
| WOS 分野 | SURGERY |
| リソース情報 | |
| ヒト・動物細胞 | RCN-9(RCB0511) |