RRC ID 41788
著者 Tsunemi T, Nagoya S, Kaya M, Kawaguchi S, Wada T, Yamashita T, Ishii S.
タイトル Postoperative progression of pulmonary metastasis in osteosarcoma.
ジャーナル Clin Orthop Relat Res
Abstract Early relapse with distant metastasis often is observed in patients with cancer after resection of the primary tumor. It is considered that resection of the primary tumor induces activation of systemic angiogenesis and enhances progression of remote metastasis. The authors show that resection of the primary osteosarcoma tumor enhances progression of pulmonary metastasis in animal osteosarcoma models. Matrigel plug neovascularization assay revealed that systemic angiogenic activity was elevated after primary tumor removal (tumor intact group, 1.61 +/- 0.21 g/dL; tumor removed group, 4.92 +/- 0.35 g/dL). In addition, serum concentration of the angiogenesis inhibitor, endostatin, decreased significantly after primary tumor removal. Treatment with the antiangiogenic reagent TNP-470 suppressed postoperative progression of pulmonary metastasis. These results indicate the possibility that activation of angiogenic activity after resection of osteosarcoma tumors enhances progression of pulmonary metastasis. The current data also suggest that administration of antiangiogenic reagents can prevent progression of pulmonary metastasis in osteosarcoma postoperatively.
巻・号 (407)
ページ 159-66
公開日 2003-2-1
DOI 10.1097/00003086-200302000-00024
PMID 12567143
MeSH Angiogenesis Inhibitors / blood Angiogenesis Inhibitors / therapeutic use* Animals Bone Neoplasms / pathology* Bone Neoplasms / prevention & control Bone Neoplasms / surgery* Collagen / blood Cyclohexanes Disease Models, Animal Endostatins Endothelial Growth Factors / blood Female Intercellular Signaling Peptides and Proteins / blood Lung Neoplasms / blood Lung Neoplasms / prevention & control* Lung Neoplasms / secondary* Lymphokines / blood Mice Mice, Inbred BALB C O-(Chloroacetylcarbamoyl)fumagillol Osteosarcoma / prevention & control Osteosarcoma / secondary* Osteosarcoma / surgery* Peptide Fragments / blood Postoperative Complications* Sesquiterpenes / blood Sesquiterpenes / therapeutic use* Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
IF 4.329
引用数 44
WOS 分野 SURGERY ORTHOPEDICS
リソース情報
ヒト・動物細胞