Reference - Detail
| RRC ID | 4180 |
|---|---|
| Author | Murphy CT, Lee SJ, Kenyon C. |
| Title | Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this "FOXO-to-FOXO" signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center. |
| Volume | 104(48) |
| Pages | 19046-50 |
| Published | 2007-11-27 |
| DOI | 10.1073/pnas.0709613104 |
| PII | 0709613104 |
| PMID | 18025456 |
| PMC | PMC2141905 |
| MeSH | Aging / genetics* Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Endoderm / physiology* Feedback, Physiological / physiology* Forkhead Transcription Factors Insulin / physiology* Intestines / physiology* Larva Longevity / genetics Peptide Hormones / genetics Peptide Hormones / physiology* Recombinant Fusion Proteins / physiology Signal Transduction Superoxide Dismutase / biosynthesis Superoxide Dismutase / genetics Transcription Factors / genetics Transcription Factors / physiology* |
| IF | 9.412 |
| Times Cited | 100 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| C.elegans | tm1907 tm2001 tm1849 tm1723 |