論文 - 詳細
| RRC ID | 41810 |
|---|---|
| 著者 | Tanigaki K, Sasaki S, Ohkuma S. |
| タイトル | In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis. |
| ジャーナル | FEBS Lett |
| Abstract |
In bafilomycin A(1)-resistant cells (Vero-317 and MC-3T3-E1), bafilomycin A(1) neither inhibited cell growth, induced cell death, nor activated caspase-3. However, 100 nM bafilomycin A(1) did raise the lysosomal pH similar to 10 mM NH(4)Cl. Prodigiosins, H(+)/Cl(-) symporters that raise the lysosomal pH, inhibited cell growth through apoptosis and caused the activation of caspase-3. Concanamycin A also inhibited the growth of these cells through apoptosis. 10 mM NH(4)Cl inhibited the growth of these cells as well, but cytostatically. These results suggest that plecomacrolides inhibited cell growth apoptotically through specific site(s), in contrast to the cytostatic effect of 10 mM NH(4)Cl, besides raising the lysosomal pH. |
| 巻・号 | 537(1-3) |
| ページ | 79-84 |
| 公開日 | 2003-2-27 |
| DOI | 10.1016/s0014-5793(03)00084-x |
| PII | S001457930300084X |
| PMID | 12606035 |
| MeSH | 3T3 Cells Animals Anti-Bacterial Agents / pharmacology* Apoptosis / drug effects Apoptosis / physiology* CHO Cells Cell Division / drug effects Cell Division / physiology* Chlorocebus aethiops Cricetinae Dose-Response Relationship, Drug Hydrogen-Ion Concentration* Kinetics Lysosomes / drug effects Lysosomes / physiology* Macrolides* Mice Prodigiosin / pharmacology* Vero Cells |
| IF | 3.057 |
| 引用数 | 23 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) Vero-317(RCB0272) |