論文 - 詳細
| RRC ID | 41813 |
|---|---|
| 著者 | Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S. |
| タイトル | Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia. |
| ジャーナル | J Nat Prod |
| Abstract |
A methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N(G)-monomethyl-l-arginine (l-NMMA), and 1 displayed the strongest activity with an IC(50) value of 6.4 microM. |
| 巻・号 | 66(2) |
| ページ | 255-8 |
| 公開日 | 2003-2-1 |
| DOI | 10.1021/np020455x |
| PMID | 12608860 |
| MeSH | Animals Anti-Inflammatory Agents / chemistry Anti-Inflammatory Agents / isolation & purification* Anti-Inflammatory Agents / pharmacology Cell Line Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology Indonesia Inhibitory Concentration 50 Lipopolysaccharides / pharmacology Macrophages / drug effects Macrophages / metabolism Mice Molecular Structure Nitric Oxide / antagonists & inhibitors* Nuclear Magnetic Resonance, Biomolecular Orthosiphon / chemistry* Plants, Medicinal / chemistry* omega-N-Methylarginine / pharmacology |
| IF | 3.782 |
| 引用数 | 30 |
| WOS 分野 | PHARMACOLOGY & PHARMACY PLANT SCIENCES CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |