Reference - Detail
RRC ID | 41838 |
---|---|
Author | Nanmoku T, Takekoshi K, Ishi K, Kawakami Y, Isobe K, Shibuya S, Okuda Y, Nakai T. |
Title | Effect of Ghrelin on catecholamine secretion in rat pheochromocytoma PC12 cells. |
Journal | Endocr Res |
Abstract |
A novel peptide Ghrelin, found to be a ligand to growth hormone (GH) secretagogue receptor (GHS-R), exeterts to stimulates GH release from pituitary gland. Recently, it has been shown that ghrelin and its receptor are existed in a adrenal ground. At concentrations of 10 nM and over (10 nM, 100 nM, and 1 microM), ghrelin significantly inhibited basal dopamine release by 30, 32 and 34%, respectively (P < 0.05) in PC12 cells, suggesting that ghrelin may be involved in the mechanism of catecholamine regulation in chromaffin cells. |
Volume | 29(1) |
Pages | 17-21 |
Published | 2003-2-1 |
DOI | 10.1081/erc-120018673 |
PMID | 12665315 |
MeSH | Animals Dopamine / metabolism* Ghrelin PC12 Cells / drug effects* PC12 Cells / metabolism* Peptide Hormones / pharmacology* Rats |
IF | 1.553 |
Times Cited | 5 |
WOS Category | ENDOCRINOLOGY & METABOLISM |
Resource | |
Human and Animal Cells | PC-12(RCB0009) |