Reference - Detail
RRC ID | 41839 |
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Author | Awale S, Tezuka Y, Banskota AH, Kadota S. |
Title | Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship. |
Journal | Biol Pharm Bull |
Abstract |
Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established. |
Volume | 26(4) |
Pages | 468-73 |
Published | 2003-4-1 |
DOI | 10.1248/bpb.26.468 |
PMID | 12673027 |
MeSH | Animals Cell Line Cell Survival / drug effects Cell Survival / physiology Diterpenes / chemistry Diterpenes / isolation & purification Diterpenes / pharmacology* Dose-Response Relationship, Drug Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / antagonists & inhibitors* Nitric Oxide / biosynthesis* Orthosiphon* Oxygen / chemistry Oxygen / isolation & purification Oxygen / pharmacology* Structure-Activity Relationship |
IF | 1.863 |
Times Cited | 23 |
WOS Category | PHARMACOLOGY & PHARMACY |
Resource | |
Human and Animal Cells | J774.1(RCB0434) |