Reference - Detail
| RRC ID | 41839 |
|---|---|
| Author | Awale S, Tezuka Y, Banskota AH, Kadota S. |
| Title | Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship. |
| Journal | Biol Pharm Bull |
| Abstract |
Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established. |
| Volume | 26(4) |
| Pages | 468-73 |
| Published | 2003-4-1 |
| DOI | 10.1248/bpb.26.468 |
| PMID | 12673027 |
| MeSH | Animals Cell Line Cell Survival / drug effects Cell Survival / physiology Diterpenes / chemistry Diterpenes / isolation & purification Diterpenes / pharmacology* Dose-Response Relationship, Drug Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / antagonists & inhibitors* Nitric Oxide / biosynthesis* Orthosiphon* Oxygen / chemistry Oxygen / isolation & purification Oxygen / pharmacology* Structure-Activity Relationship |
| IF | 1.863 |
| Times Cited | 23 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |