論文 - 詳細
| RRC ID | 41842 |
|---|---|
| 著者 | Choi EM, Hwang JK. |
| タイトル | Effects of (+)-catechin on the function of osteoblastic cells. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are candidate cytokines which are produced by osteoblastic linage cells and promote osteoblast apoptosis, osteoclastogenesis and bone resorption. Here, we examined the effect of (+)-catechin, one of the most common grape flavonols, on osteoblastic MC3T3-E1 cells. (+)-Catechin caused a significant elevation of cell survival at 10(-5) and 10(-4) M and alkaline phosphatase activity at 10(-5) M. Also, treatment with (+)-catechin (10(-5) M) decreased bone-resorbing cytokines (TNF-alpha and IL-6) production and apoptosis in osteoblasts. Our data indicate that the reduction of bone-resorbing cytokines and apoptosis in osteoblasts by (+)-catechin may result in the prevention and therapy for osteoporosis and inflammatory bone diseases. |
| 巻・号 | 26(4) |
| ページ | 523-6 |
| 公開日 | 2003-4-1 |
| DOI | 10.1248/bpb.26.523 |
| PMID | 12673036 |
| MeSH | Animals Apoptosis / drug effects Apoptosis / physiology Catechin / pharmacology* Cell Line Cell Survival / drug effects Cell Survival / physiology Interleukin-6 / biosynthesis Mice Osteoblasts / drug effects* Osteoblasts / physiology* Tumor Necrosis Factor-alpha / biosynthesis |
| IF | 1.863 |
| 引用数 | 37 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |