Reference - Detail
RRC ID | 4184 |
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Author | Rand JB. |
Title | Acetylcholine. |
Journal | WormBook |
Abstract |
Acetylcholine is the major excitatory neurotransmitter at nematode neuromuscular junctions, and more than a third of the cells in the C. elegans nervous system release acetylcholine. Through a combination of forward genetics, drug-resistance selections, and genomic analysis, mutants have been identified for all of the steps specifically required for cholinergic function. These include two enzymes, two transporters, and a bewildering assortment of receptors. Cholinergic transmission is involved, directly or indirectly, in many C. elegans behaviors, including locomotion, egg laying, feeding, and male mating. |
Pages | 1-21 |
Published | 2007-1-30 |
DOI | 10.1895/wormbook.1.131.1 |
PMID | 18050502 |
PMC | PMC4781110 |
MeSH | Acetylcholine / biosynthesis Acetylcholine / physiology* Acetylcholinesterase / metabolism Animals Biological Transport Caenorhabditis elegans / drug effects Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Choline / metabolism Cytoplasmic Vesicles / physiology Humans Receptors, Cholinergic / genetics Receptors, Cholinergic / metabolism |
Resource | |
C.elegans | tm373 |