Reference - Detail
| RRC ID | 41862 |
|---|---|
| Author | Ohguchi K, Tanaka T, Iliya I, Ito T, Iinuma M, Matsumoto K, Akao Y, Nozawa Y. |
| Title | Gnetol as a potent tyrosinase inhibitor from genus Gnetum. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells. |
| Volume | 67(3) |
| Pages | 663-5 |
| Published | 2003-3-1 |
| DOI | 10.1271/bbb.67.663 |
| PMID | 12723623 |
| MeSH | Animals Gnetum / chemistry* Inhibitory Concentration 50 Melanins / biosynthesis Melanoma, Experimental / metabolism Mice Peptides / chemistry Peptides / pharmacology* Pyrones / pharmacology Stilbenes / chemistry Stilbenes / pharmacology* |
| IF | 1.516 |
| Times Cited | 52 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | B16 melanoma |