論文 - 詳細
| RRC ID | 41912 |
|---|---|
| 著者 | Takahashi T, Haraguchi K, Chiba S, Yasukawa M, Shibata Y, Hirai H. |
| タイトル | Valpha24+ natural killer T-cell responses against T-acute lymphoblastic leukaemia cells: implications for immunotherapy. |
| ジャーナル | Br J Haematol |
| Abstract |
Human Valpha24+ natural killer T (NKT) cells correspond to mouse Valpha14+ NKT cells, both cell types use an invariant T-cell receptor-alpha chain and are activated by glycolipids in a CD1d-dependent manner. Mouse Valpha14+ NKT cells have been reported to have an antitumour effect in vivo. Human Valpha24+ NKT cells can kill a proportion of tumour cells in a CD1d-dependent manner in vitro. We report here that many human leukaemic T-cell lines express CD1d and can be directly killed by Valpha24+ NKT cells. This killing activity was enhanced in the presence of alpha-galactosylceramide (alpha-GalCer), a ligand of Valpha24+ NKT cells. Moreover, primary leukaemic T cells from five of eight T-cell acute lymphoblastic leukaemia (T-ALL) patients expressed CD1d and were good targets of Valpha24+ NKT cells. This cytotoxicity was increased in the presence of alpha-GalCer. Our results suggest that T-ALL is a good candidate for Valpha24+ NKT-cell-based immuno-cell therapy. |
| 巻・号 | 122(2) |
| ページ | 231-9 |
| 公開日 | 2003-7-1 |
| DOI | 10.1046/j.1365-2141.2003.04429.x |
| PII | 4429 |
| PMID | 12846891 |
| MeSH | Antigens, CD1 / analysis Cytokines / immunology Cytotoxicity Tests, Immunologic Humans Immunophenotyping Immunotherapy, Adoptive / methods* Killer Cells, Natural / immunology* Leukemia-Lymphoma, Adult T-Cell / immunology* Lymphocyte Activation Receptors, Antigen, T-Cell, alpha-beta / immunology* Tumor Cells, Cultured |
| IF | 5.518 |
| 引用数 | 25 |
| WOS 分野 | HEMATOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | K562(RCB0027) |