| RRC ID |
41920
|
| 著者 |
Lee SJ, Sakurai H, Oshima K, Kim SH, Saiki I.
|
| タイトル |
Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b.
|
| ジャーナル |
Eur J Cancer
|
| Abstract |
We investigated the anti-metastatic and anti-angiogenic effects of TN-6b, a new broad-spectrum inhibitor of matrix metalloproteinases (MMPs), against Lewis lung carcinoma (LLC) and hepatic sinusoidal endothelial (HSE) cells. TN-6b potently inhibited the activities of MMP-2 and -9 secreted by LLC and HSE cells in a zymogram assay. TN-6b, at non-cytotoxic concentrations, caused a marked inhibition of invasion and migration of LLC, and tube-like formation of HSE cells. In contrast, TN-6d, an inactive enantiomer of TN-6b, did not inhibit the invasion and tube-like formation. Daily subcutaneous (s.c.) administration of TN-6b at doses of 30 and 60 mg/kg in mice resulted in a potent inhibition of tumour-induced angiogenesis of B16 melanomas and lymph node metastasis of LLC cells. In conclusion, TN-6b effectively inhibited lymph node metastasis of LLC cells through its anti-invasive and anti-angiogenic properties. These findings suggest that the MMP inhibition correlates well with its anti-angiogenic and anti-metastatic efficacy and TN-6b has the therapeutic potential to inhibit angiogenesis and metastasis in vivo and in vitro.
|
| 巻・号 |
39(11)
|
| ページ |
1632-41
|
| 公開日 |
2003-7-1
|
| DOI |
10.1016/s0959-8049(03)00375-7
|
| PII |
S0959804903003757
|
| PMID |
12855272
|
| MeSH |
Angiogenesis Inhibitors / therapeutic use*
Animals
Benzene Derivatives / therapeutic use
Carcinoma, Lewis Lung / drug therapy*
Carcinoma, Lewis Lung / pathology
Cell Division
Enzyme Inhibitors / therapeutic use*
Lymphatic Metastasis / prevention & control
Matrix Metalloproteinase Inhibitors*
Melanoma, Experimental / drug therapy*
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Tumor Cells, Cultured
|
| IF |
7.275
|
| 引用数 |
13
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
NB1RGB(RCB0222) |
