| RRC ID |
41929
|
| 著者 |
Li X, Bukawa H, Hirota M, Tsuyuki Y, Omura S, Fujita K.
|
| タイトル |
Novel OK-432-conjugated tumor vaccines induce tumor-specific immunity against murine tongue cancer.
|
| ジャーナル |
J Dent Res
|
| Abstract |
Priming with tumor antigens is one of the most important strategies in cancer immunotherapy. To enhance tumor antigenicity, OK-432, a streptococcal preparation, was coupled to squamous cell carcinoma (KLN-205) by means of a 0.2% glutaraldehyde method. The purpose of this study was to investigate whether OK-432-conjugated tumor vaccines could induce tumor-specific immunity. Our originally developed mouse tongue cancer model was used throughout this work for the analysis of antitumor effects. Prepared OK-432-conjugated KLN-205 vaccines were immunized 3 times to DBA/2 mice. The results showed that the KLN-205 vaccines induced cytolytic activity and strongly suppressed both KLN-205 tumor incidence and growth, and survival of the mice was improved. Moreover, the histological results showed that a greater number of lymphocytes had infiltrated around tumor cells by 24 hours after tumor inoculation in the vaccine group. These results suggest that immunizations with KLN-205 vaccines increase the antitumor effects against tongue cancer.
|
| 巻・号 |
82(8)
|
| ページ |
636-40
|
| 公開日 |
2003-8-1
|
| DOI |
10.1177/154405910308200813
|
| PMID |
12885850
|
| MeSH |
Animals
Antigens, Neoplasm / immunology
Antineoplastic Agents / immunology*
Cancer Vaccines*
Carcinoma, Squamous Cell / immunology
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / prevention & control*
Disease Models, Animal
Female
Immunization
Lymphocytes / immunology
Mice
Mice, Inbred DBA
Picibanil / immunology*
Survival Rate
Tongue Neoplasms / immunology
Tongue Neoplasms / pathology
Tongue Neoplasms / prevention & control*
Vaccines, Conjugate
|
| IF |
4.914
|
| 引用数 |
2
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma(RCB1283)
Sq-1979(RCB0284) |
