| RRC ID |
41949
|
| Author |
Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.
|
| Title |
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
|
| Journal |
J Nat Prod
|
| Abstract |
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
|
| Volume |
66(8)
|
| Pages |
1124-7
|
| Published |
2003-8-1
|
| DOI |
10.1021/np020546u
|
| PMID |
12932141
|
| MeSH |
Apoptosis / drug effects*
Blotting, Western
Garcinia / chemistry*
HL-60 Cells / drug effects
Humans
Indonesia
Inhibitory Concentration 50
Leukemia
Molecular Structure
Plants, Medicinal / chemistry*
Stereoisomerism
Tumor Cells, Cultured / drug effects
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology
|
| IF |
3.782
|
| Times Cited |
144
|
|
WOS Category
|
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
|
| Resource |
| Human and Animal Cells |
K562(RCB0027)
HL60(RCB0041)
U-937 DE-4(RCB0435) |
