Reference - Detail
| RRC ID | 41955 |
|---|---|
| Author | Yoshida K. |
| Title | Fibroblast cell shape and adhesion in vitro is altered by overexpression of the 7a and 7b isoforms of protocadherin 7, but not the 7c isoform. |
| Journal | Cell Mol Biol Lett |
| Abstract |
Protocadherins (Pcdhs) are a family of cadherins considered to play an important role in the cell-cell adhesion of specific neurons in the central nervous system. Of the reported Pcdhs, relatively little is known about the functional role of protocadherin 7 (Pcdh7), and there is no evidence of Pcdh7 mediated cell-cell adhesion. To date, three splicing variants are known; they may have different effects on cell phenotype. We report here that mouse fibroblast L cells stably overexpressing the Pcdh7 isoforms 7a and 7b, but not 7c, showed a morphological change and Ca(2+)dependent cell adhesion. |
| Volume | 8(3) |
| Pages | 735-41 |
| Published | 2003-1-1 |
| PMID | 12949613 |
| MeSH | Animals Blotting, Western Cadherins / genetics Cadherins / metabolism* Cell Adhesion Cell Size Fibroblasts / cytology Fibroblasts / metabolism* Immunohistochemistry L Cells Mice Protein Isoforms / genetics Protein Isoforms / metabolism |
| IF | 3.451 |
| Times Cited | 30 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | |