論文 - 詳細
| RRC ID | 41964 |
|---|---|
| 著者 | Murakami Y, Shoji M, Hanazawa S, Tanaka S, Fujisawa S. |
| タイトル | Preventive effect of bis-eugenol, a eugenol ortho dimer, on lipopolysaccharide-stimulated nuclear factor kappa B activation and inflammatory cytokine expression in macrophages. |
| ジャーナル | Biochem Pharmacol |
| Abstract |
Eugenol exhibits antioxidant and anti-inflammatory activities, but at higher concentrations acts as an oxidant and potent allergen. It was earlier shown that bis-eugenol synthesized by the oxidation of eugenol was less cytotoxic and more highly antioxidative than eugenol. But its anti-inflammatory mechanism remains yet unclear. Since nuclear factor-kappa B (NF-kappa B) is a key transcriptional factor in the expression of inflammatory cytokines, we examined whether eugenol and bis-eugenol are inhibitors of NF-kappa B activation. We observed that bis-eugenol, but not eugenol, clearly inhibited the degradation of inhibitory kappa B-alpha in RAW264.7 murine macrophages stimulated with lipopolysaccharide and, consequently, the transcriptional activity of the stimulated NF-kappa B in the cells. In addition, bis-eugenol actually inhibited LPS-stimulated expression of inflammatory cytokines at both gene and protein levels. These findings suggest that bis-eugenol acts as a potent inhibitor of NF-kappa B. |
| 巻・号 | 66(6) |
| ページ | 1061-6 |
| 公開日 | 2003-9-15 |
| DOI | 10.1016/s0006-2952(03)00419-2 |
| PII | S0006295203004192 |
| PMID | 12963494 |
| MeSH | Animals Cytokines / metabolism* Dimerization Eugenol / pharmacology* Inflammation Lipopolysaccharides / pharmacology* Macrophage Activation Macrophages / drug effects* Mice NF-kappa B / metabolism* |
| IF | 4.96 |
| 引用数 | 48 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |