論文 - 詳細
| RRC ID | 41986 |
|---|---|
| 著者 | Ueda JY, Tezuka Y, Banskota AH, Tran QL, Tran QK, Saiki I, Kadota S. |
| タイトル | Antiproliferative activity of cardenolides isolated from Streptocaulon juventas. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine-derived (colon 26-L5 carcinoma, Lewis lung carcinoma, B16-BL6 melanoma) cell lines. The cardenolides selectively and strongly inhibited proliferation of the HT-1080 (IC(50) values, 0.054-1.6 microM) and A549 (IC(50), 0.016-0.65 microM) cell lines. The characteristic morphological changes and ladder-like DNA fragmentation in those cells treated with the cardenolides indicated the antiproliferative activity was due to the induction of apoptosis. |
| 巻・号 | 26(10) |
| ページ | 1431-5 |
| 公開日 | 2003-10-1 |
| DOI | 10.1248/bpb.26.1431 |
| PMID | 14519950 |
| MeSH | Animals Apocynaceae* Cardenolides / chemistry Cardenolides / isolation & purification Cardenolides / pharmacology* Cell Line, Tumor DNA Fragmentation / drug effects DNA Fragmentation / physiology Growth Inhibitors / chemistry Growth Inhibitors / isolation & purification Growth Inhibitors / pharmacology* Humans Mice Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Plant Roots |
| IF | 1.863 |
| 引用数 | 21 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) A549(RCB0098) |