論文 - 詳細
| RRC ID | 41997 |
|---|---|
| 著者 | Yamasaki Y, Yoshida Y, Okazaki M, Shimazu A, Kubo T, Akagawa Y, Uchida T. |
| タイトル | Action of FGMgCO3Ap-collagen composite in promoting bone formation. |
| ジャーナル | Biomaterials |
| Abstract |
To improve the biological properties of materials as bone substitutes, functionally graded CO3 apatite crystals containing magnesium, FGMgCO3Ap, were synthesized to be mixed with atelocollagen and made into a composite pellet. A radio-labeled cell adhesion experiment showed that the degree of adherence of mouse MC3T3E1 osteoblast-like cells to the FGMgCO3Ap-collagen composite was better than to CO3Ap-collagen and much better than to the Ti plate. When the composites were implanted beneath the periosteum cranii of rats, the FGMgCO3Ap-collagen composite was metabolized faster than the CO3Ap-collagen composite and better formation of new bone and osteoblast arrangement at the interface between the composite and the periosteum cranii was observed. When the composites were implanted into the femur of rabbits, clear bone formation with a higher degree of bone density was observed for the FGMgCO3Ap-collagen composite. These results suggest that the Mg2+ ions taken into the apatite crystals may contribute to the acceleration of osteoblast adhesion to apatites and promote bone formation, cross-talking with osteoblasts at the molecular level. |
| 巻・号 | 24(27) |
| ページ | 4913-20 |
| 公開日 | 2003-12-1 |
| DOI | 10.1016/s0142-9612(03)00414-9 |
| PII | S0142961203004149 |
| PMID | 14559004 |
| MeSH | 3-Hydroxysteroid Dehydrogenases Aldo-Keto Reductase Family 1 Member C3 Animals Biocompatible Materials / chemical synthesis Biocompatible Materials / chemistry* Bone Density / physiology* Bone Development / physiology* Bone Substitutes / chemical synthesis Bone Substitutes / chemistry* Cell Adhesion / physiology* Cell Line Collagen / chemistry* Femur / cytology Femur / growth & development Hydroxyprostaglandin Dehydrogenases / antagonists & inhibitors Hydroxyprostaglandin Dehydrogenases / chemistry* Male Manufactured Materials Materials Testing Mice Osseointegration / physiology* Osteoblasts / cytology Osteoblasts / physiology Rabbits Rats Rats, Wistar Skull / cytology Skull / growth & development |
| IF | 10.317 |
| 引用数 | 124 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |