Reference - Detail
RRC ID | 42008 |
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Author | Murakami M, Ikeda T, Ogawa K, Funaba M. |
Title | Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. |
Journal | Biochem Biophys Res Commun |
Abstract |
We explored transcriptional regulation of mouse mast cell protease-9 (mMCP-9), which is implicated in inflammation of the jejunum during helminth infections and tissue remodeling of the uterus during pregnancy. Transcription was positively regulated by microphthalmia-associated transcription factor (MITF), a member of the basic helix-loop-helix-leucine zipper family that binds to the E-box, a CANNTG sequence. The most significant segment for positive regulation by MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which bound MITF-M. In addition, not only other MITF isoforms but also TFE3, another member of the family, activated mMCP-9 transcription through this nucleotide sequence inserted one base within the E-box. |
Volume | 311(1) |
Pages | 4-10 |
Published | 2003-11-7 |
DOI | 10.1016/j.bbrc.2003.09.148 |
PII | S0006291X03019661 |
PMID | 14575687 |
MeSH | Amino Acid Motifs Animals DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Female Gene Expression Regulation, Enzymologic / physiology* Humans Male Mast Cells / chemistry Mast Cells / enzymology* Melanoma, Experimental / chemistry Melanoma, Experimental / enzymology* Melanoma, Experimental / genetics Mice Microphthalmia-Associated Transcription Factor Protein Binding Serine Endopeptidases / chemistry Serine Endopeptidases / genetics Serine Endopeptidases / metabolism* Transcription Factors / chemistry Transcription Factors / genetics Transcription Factors / metabolism* Transcriptional Activation / genetics Transcriptional Activation / physiology* Up-Regulation / physiology |
IF | 2.985 |
Times Cited | 13 |
WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
Human and Animal Cells | Hep G2 |