| RRC ID |
42039
|
| 著者 |
Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, K-Tsuzuku J, Yamamoto T, Hayashi S, Nagasawa K, Sueoka E.
|
| タイトル |
Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Tob is a member of the Tob/BTG family, a novel class of anti-proliferative proteins. To investigate the involvement of tob as a tumor suppressor gene in human lung cancer, we analyzed the expression of tob mRNA and protein in lung cancer tissue and adjacent normal lung tissue. Immunohistochemical analysis using anti-Tob antibody showed decreased expression of Tob in 72% (31/43) of lung cancer tissues. Furthermore, 95% (19/20) of squamous cell carcinoma patients showed an apparent decrease in Tob in cancer tissues, associated with smoking status. The phosphorylated form of Tob, an inactive form of Tob, was detected in 76% (16/21) of cancer tissues of adenocarcinoma patients, but not in normal alveolar epithelial cells. Either a decrease in Tob expression or an accumulation of phosphorylated Tob was observed from early clinical stages, even in bronchial dysplasia, a premalignant lesion of squamous cell carcinoma. The above findings suggest that the disruption of anti-proliferative Tob plays a distinct part in the early stage of lung carcinogenesis.
|
| 巻・号 |
202(1)
|
| ページ |
71-9
|
| 公開日 |
2003-12-8
|
| DOI |
10.1016/j.canlet.2003.08.019
|
| PII |
S0304383503005779
|
| PMID |
14643028
|
| MeSH |
Adenocarcinoma / metabolism
Adenocarcinoma / pathology
Aged
Bronchi / pathology
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / pathology
Carrier Proteins / genetics*
Carrier Proteins / metabolism*
Epithelial Cells / metabolism
Epithelial Cells / pathology
Female
Genes, Tumor Suppressor*
Humans
Immunoenzyme Techniques
Immunoglobulin G / immunology
Intracellular Signaling Peptides and Proteins*
Lung Neoplasms / diagnostic imaging
Lung Neoplasms / metabolism*
Lung Neoplasms / pathology
Male
Neoplasm Staging
Phosphorylation
Precancerous Conditions / metabolism
Precancerous Conditions / pathology
RNA, Messenger / metabolism
RNA, Neoplasm / genetics
Radiography
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Proteins*
|
| IF |
7.36
|
| 引用数 |
39
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
MS-1(RCB0725) |
