論文 - 詳細
| RRC ID | 42074 |
|---|---|
| 著者 | Hara T, Ishii T, Fujishiro M, Masuda M, Ito T, Nakajima J, Inoue T, Matsuse T. |
| タイトル | Glutathione S-transferase P1 has protective effects on cell viability against camptothecin. |
| ジャーナル | Cancer Lett |
| Abstract |
Glutathione S-transferase P1 (GSTP1) is one of the important xenobiotic-metabolizing enzymes. It was reported that GSTP1 was overexpressed in malignant tissues, and its expression level was associated with resistance to chemotherapeutics. We carried out transfection of GSTP1 sense and antisense vectors to examine effects of GSTP1 on cell cycle arrest and apoptosis induced by camptothecin in HeLa cells. Transfection of GSTP1 antisense vector induced apoptosis. Camptothecin-induced S- or G2/M arrest was intensified by transfection of GSTP1 antisense vector, and subsequent apoptosis was attenuated by transfection of GSTP1 sense vector. These results suggest that GSTP1 has protective effects against camptothecin-induced cytotoxicity. |
| 巻・号 | 203(2) |
| ページ | 199-207 |
| 公開日 | 2004-1-20 |
| DOI | 10.1016/j.canlet.2003.09.005 |
| PII | S0304383503005895 |
| PMID | 14732228 |
| MeSH | Antineoplastic Agents, Phytogenic / pharmacology Apoptosis Camptothecin / pharmacology* Cell Cycle Cell Division Cell Separation Cell Survival / drug effects DNA / metabolism Dose-Response Relationship, Drug Flow Cytometry G2 Phase Genetic Vectors Glutathione S-Transferase pi Glutathione Transferase / physiology* HeLa Cells Humans Immunoblotting Magnetics Mitosis Oligonucleotides, Antisense / pharmacology S Phase Time Factors Transfection Xenobiotics / pharmacology |
| IF | 7.36 |
| 引用数 | 9 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |