| RRC ID |
42078
|
| 著者 |
Shibata Y, Kawai H, Yamamoto H, Igarashi T, Miyazaki T.
|
| タイトル |
Antibacterial titanium plate anodized by being discharged in NaCl solution exhibits cell compatibility.
|
| ジャーナル |
J Dent Res
|
| Abstract |
Implant surfaces should be modified to achieve excellent cell compatibility as well as antibacterial activity. Our previous study demonstrated that titanium plates anodized by being discharged in NaCl (Ti-Cl) exhibited high antibacterial activity. Since Ti-Cl was prepared with a NaCl solution, we hypothesized that Ti-Cl would exhibit low toxicity toward cells. The aims of this study were to characterize the surface of Ti-Cl and investigate the cell compatibility (MC3T3-E1 and L929 cells) of Ti-Cl. The results demonstrated that, since the TiCl(3) formed on the Ti-Cl surface was hydrolyzed into HCl, HClO, and TiOH after immersion in pure distilled water, TiCl(3) contributed to the antibacterial activity of Ti-Cl. On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control. These findings suggest that antibacterial titanium is a promising material for use in dental implant systems.
|
| 巻・号 |
83(2)
|
| ページ |
115-9
|
| 公開日 |
2004-2-1
|
| DOI |
10.1177/154405910408300206
|
| PMID |
14742647
|
| MeSH |
3T3 Cells
Adsorption
Animals
Anti-Bacterial Agents / chemistry*
Biocompatible Materials / chemistry*
Cell Adhesion
Cell Division
Cell Line
Fibroblasts / cytology
Fibronectins / chemistry
Hydrochloric Acid / chemistry
Hydrolysis
Hypochlorous Acid / chemistry
Materials Testing
Mice
Osteoblasts / cytology
Sodium Chloride / chemistry*
Surface Properties
Titanium / chemistry*
|
| IF |
4.914
|
| 引用数 |
27
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126)
L929 |
