論文 - 詳細
| RRC ID | 42083 |
|---|---|
| 著者 | Antony P, Petro JB, Carlesso G, Shinners NP, Lowe J, Khan WN. |
| タイトル | B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol. |
| ジャーナル | Biochem Soc Trans |
| Abstract |
Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-gamma2 (PLC-gamma2) are required to activate NFAT and NF-kappaB, and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-gamma2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-kappaB. |
| 巻・号 | 32(Pt 1) |
| ページ | 113-5 |
| 公開日 | 2004-2-1 |
| DOI | 10.1042/bst0320113 |
| PMID | 14748726 |
| MeSH | Agammaglobulinaemia Tyrosine Kinase Animals Cell Line Chickens Chromatography, Thin Layer DNA-Binding Proteins / metabolism* Diglycerides / metabolism* NF-kappa B / metabolism* NFATC Transcription Factors Nuclear Proteins* Protein-Tyrosine Kinases / metabolism Receptors, Antigen, B-Cell / metabolism* Transcription Factors / metabolism* |
| IF | 5.16 |
| 引用数 | 20 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | |