RRC ID 42083
著者 Antony P, Petro JB, Carlesso G, Shinners NP, Lowe J, Khan WN.
タイトル B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.
ジャーナル Biochem Soc Trans
Abstract Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-gamma2 (PLC-gamma2) are required to activate NFAT and NF-kappaB, and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-gamma2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-kappaB.
巻・号 32(Pt 1)
ページ 113-5
公開日 2004-2-1
DOI 10.1042/bst0320113
PMID 14748726
MeSH Agammaglobulinaemia Tyrosine Kinase Animals Cell Line Chickens Chromatography, Thin Layer DNA-Binding Proteins / metabolism* Diglycerides / metabolism* NF-kappa B / metabolism* NFATC Transcription Factors Nuclear Proteins* Protein-Tyrosine Kinases / metabolism Receptors, Antigen, B-Cell / metabolism* Transcription Factors / metabolism*
IF 5.16
引用数 20
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞