| RRC ID |
42083
|
| 著者 |
Antony P, Petro JB, Carlesso G, Shinners NP, Lowe J, Khan WN.
|
| タイトル |
B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.
|
| ジャーナル |
Biochem Soc Trans
|
| Abstract |
Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-gamma2 (PLC-gamma2) are required to activate NFAT and NF-kappaB, and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-gamma2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-kappaB.
|
| 巻・号 |
32(Pt 1)
|
| ページ |
113-5
|
| 公開日 |
2004-2-1
|
| DOI |
10.1042/bst0320113
|
| PMID |
14748726
|
| MeSH |
Agammaglobulinaemia Tyrosine Kinase
Animals
Cell Line
Chickens
Chromatography, Thin Layer
DNA-Binding Proteins / metabolism*
Diglycerides / metabolism*
NF-kappa B / metabolism*
NFATC Transcription Factors
Nuclear Proteins*
Protein-Tyrosine Kinases / metabolism
Receptors, Antigen, B-Cell / metabolism*
Transcription Factors / metabolism*
|
| IF |
5.16
|
| 引用数 |
20
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
