RRC ID |
42111
|
Author |
Tsukushi Y, Kido N, Saeki K, Sugiyama T, Koide N, Mori I, Yoshida T, Yokochi T.
|
Title |
Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium.
|
Journal |
J Endotoxin Res
|
Abstract |
The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-alpha and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.
|
Volume |
10(1)
|
Pages |
25-31
|
Published |
2004-1-1
|
DOI |
10.1179/096805104225003799
|
PMID |
15025821
|
MeSH |
Animals
Biological Assay
Escherichia coli / pathogenicity
Horseshoe Crabs
Lipopolysaccharides / isolation & purification*
Lipopolysaccharides / pharmacology*
Nitric Oxide / analysis
Proteobacteria / pathogenicity*
Sinorhizobium / pathogenicity*
Structure-Activity Relationship
Tumor Necrosis Factor-alpha / biosynthesis
|
Times Cited |
8
|
WOS Category
|
MEDICINE, RESEARCH & EXPERIMENTAL
IMMUNOLOGY
MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
Resource |
Human and Animal Cells |
RAW 264(RCB0535) |