論文 - 詳細
| RRC ID | 42126 |
|---|---|
| 著者 | Ogasawara M, Suzuki H. |
| タイトル | Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Tumor cell motility plays a crucial role in the establishment of tumor metastasis and is affected by a variety of host-derived factors during the event. Hepatocyte growth factor (HGF) is one of these factors and stimulates tumor cell migration remarkably. We previously reported that evodiamine has a marked inhibitory activity on tumor cell invasion and migration in vitro. In this study, the effects of evodiamine on HGF-induced invasion and migration of tumor cell lines, colon 26-L5 carcinoma, B16-F10 melanoma and Lewis lung carcinoma (LLC) were examined. HGF promoted invasive activity of tumor cell lines with maximal induction of 1.8 times at 30 ng/ml for colon 26-L5 and LLC cells, and 2.0 times at 10 ng/ml for B16-F10 cells. Evodiamine inhibited the HGF-stimulated tumor cell invasion and migration in a concentration-dependent manner, and achieved complete suppression at 30 microM in all of the cell lines tested. When tumor cells were seeded on fibronectin-coated plates with evodiamine, their spreading on the plate was obviously inhibited, while their adhesiveness to fibronectin was unaffected. Evodiamine showed a marginal effect on tumor cell growth in a 24-h incubation, although it exhibited a marked inhibition in an over 48-h incubation. These results suggest that evodiamine suppressed HGF-stimulated invasion and migration of tumor cells partly through inhibition of cell spreading. |
| 巻・号 | 27(4) |
| ページ | 578-82 |
| 公開日 | 2004-4-1 |
| DOI | 10.1248/bpb.27.578 |
| PMID | 15056871 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / pharmacology* Carcinoma, Lewis Lung Cell Adhesion / drug effects Cell Line, Tumor Cell Movement / drug effects* Cell Proliferation / drug effects Colonic Neoplasms Evodia / chemistry Hepatocyte Growth Factor / physiology* Melanoma, Experimental Mice Neoplasm Invasiveness / pathology* Plant Extracts / pharmacology* Quinazolines / pharmacology* |
| IF | 1.863 |
| 引用数 | 27 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |