論文 - 詳細
| RRC ID | 42132 |
|---|---|
| 著者 | Tomita N, Sando S, Sera T, Aoyama Y. |
| タイトル | Macrocyclic proteoglycan mimics. Potent inhibition of cell adhesion by a bundle of chondroitin sulfate chains assembled on the calix[4]resorcarene platform. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Tailed calix[4]resorcarene macrocycle (tail=undecyl) can be used as a platform to assemble four glycosaminoglycan polysaccharide chains to give a new type of proteoglycan mimics. A tetra(chondroitin sulfate) derivative thus obtained from the reaction of macrocyclic octaamine and chondroitin sulfate lactone is readily immobilized on a tissue culture plastic (polystyrene) plate and inhibits fibronectin-mediated adhesion of BHK (baby hamster kidney) cells thereon remarkably strongly with 50% inhibition occurring at a 10 ng/mL or 40 pM concentration range. |
| 巻・号 | 14(9) |
| ページ | 2087-90 |
| 公開日 | 2004-5-3 |
| DOI | 10.1016/j.bmcl.2004.02.041 |
| PII | S0960894X04002471 |
| PMID | 15080984 |
| MeSH | Animals Calixarenes / chemistry* Cell Adhesion / drug effects* Cell Line Chondroitin Sulfates / chemistry Chondroitin Sulfates / pharmacology* Cricetinae Macrocyclic Compounds / chemistry* Molecular Mimicry* Proteoglycans / chemistry Proteoglycans / pharmacology* |
| IF | 2.572 |
| 引用数 | 6 |
| WOS 分野 | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | |