| RRC ID |
42208
|
| Author |
Aoki S, Kong D, Matsui K, Rachmat R, Kobayashi M.
|
| Title |
Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.
|
| Volume |
52(8)
|
| Pages |
935-7
|
| Published |
2004-8-1
|
| DOI |
10.1248/cpb.52.935
|
| PII |
JST.JSTAGE/cpb/52.935
|
| PMID |
15304984
|
| MeSH |
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cell Differentiation / drug effects*
Erythroblasts / chemistry
Erythroblasts / cytology
Erythroblasts / drug effects*
Hemoglobins / metabolism
Humans
K562 Cells
Porifera / chemistry*
Quinones / chemistry
Quinones / isolation & purification*
Quinones / pharmacology
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured
|
| IF |
1.416
|
| Times Cited |
36
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
CHEMISTRY, MULTIDISCIPLINARY
|
| Resource |
| Human and Animal Cells |
K562 |
