論文 - 詳細
| RRC ID | 42212 |
|---|---|
| 著者 | Arakawa Y, Kajino K, Kano S, Tobita H, Hayashi J, Yasen M, Moriyama M, Arakawa Y, Hino O. |
| タイトル | Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Human hepatocellular carcinoma is one of the most common cancers in the world. We previously showed that dbpA, a member of the Y box family of proteins, could accelerate the process of inflammation-induced hepatocarcinogenesis, and that dbpA is more abundantly expressed in hepatocellular carcinoma than in non-tumorous tissue. In this study, to clarify the mechanism by which expression of dbpA is enhanced in the proliferative state, we examined the transcriptional activity of the dbpA promoter region. We focused on the sequence 5'-TTTGGGGC-3' (-8 to -1 in the promoter region) resembling the E2F binding site (one base mismatch, TFSEARCH score 86.2). By overexpressing E2F1 in Huh-7 cells, transcriptional activity of dbpA was significantly increased, and this increase was abolished by mutating or deleting this sequence. Thus, expression of dbpA was positively regulated by E2F1, suggesting that one of the effects of E2F1 on cell proliferation might be mediated by dbpA at the carcinogenesis step. |
| 巻・号 | 322(1) |
| ページ | 297-302 |
| 公開日 | 2004-9-10 |
| DOI | 10.1016/j.bbrc.2004.04.208 |
| PII | S0006-291X(04)01568-2 |
| PMID | 15313206 |
| MeSH | Animals CCAAT-Enhancer-Binding Proteins Carcinoma, Hepatocellular / genetics Carcinoma, Hepatocellular / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Cell Line, Tumor DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* E2F Transcription Factors E2F1 Transcription Factor Gene Expression Regulation, Neoplastic / genetics Heat-Shock Proteins / genetics Heat-Shock Proteins / metabolism* Hepatectomy Humans Liver / metabolism* Liver / surgery Liver Neoplasms / genetics Liver Neoplasms / metabolism* Male Mice Mice, Inbred C57BL Transcription Factors / genetics Transcription Factors / metabolism* Transcriptional Activation* |
| IF | 2.985 |
| 引用数 | 33 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7(RCB1366) |