RRC ID 42216
著者 Aoki S, Kong D, Matsui K, Kobayashi M.
タイトル Erythroid differentiation in K562 chronic myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid.
ジャーナル Anticancer Res
Abstract The differentiation induction of K562 chronic myelogenous leukemia (CML) cells by crambescidin 800, a pentacyclic guanidine alkaloid isolated from a marine sponge, was examined. Crambescidin 800 increased hemoglobin production in K562 cells at concentrations of 0.15-1 microM and arrested the cell cycle of K562 cells at the S-phase. The expression of p21 was detected after 24-h treatment with crambescidin 800, and an increase of the expression was observed after 48-h treatment, but there was no remarkable change in the expression level of p27. This evidence indicates that crambescidin 800 induced the differentiation of K562 cells into erythroblasts accompanied by cell cycle arrest at the S-phase. Furthermore, crambescidin 800 induced a morphological change with neurite outgrowth in Neuro 2A cells at a 0.03-0.1 microM concentration.
巻・号 24(4)
ページ 2325-30
公開日 2004-1-1
PMID 15330179
MeSH Alkaloids / pharmacology* Animals Cell Cycle / drug effects Cell Differentiation / drug effects Erythroid Cells / drug effects Erythroid Cells / pathology Guanidine / analogs & derivatives Guanidine / pharmacology* Guanidines / pharmacology Hemoglobins / biosynthesis Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy* Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology* Porifera / chemistry Spiro Compounds / pharmacology*
IF 1.994
引用数 35
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 K562