論文 - 詳細
| RRC ID | 42260 |
|---|---|
| 著者 | Takanami I, Inoue Y, Gika M. |
| タイトル | G-protein inwardly rectifying potassium channel 1 (GIRK 1) gene expression correlates with tumor progression in non-small cell lung cancer. |
| ジャーナル | BMC Cancer |
| Abstract |
BACKGROUND:G-protein inwardly rectifying potassium channel 1 (GIRK1) is thought to play a role in cell proliferation in cancer, and GIRK1 gene expression level may define a more aggressive phenotype. We detected GIRK1 expression in tissue specimens from patients with non-small cell lung cancers (NSCLCs) and assessed their clinical characteristics. METHODS:Using reverse transcription-polymerase chain reaction (RT-PCR) analyses, we quantified the expression of GIRK1 in 72 patients with NSCLCs to investigate the relationship between GIRK1 expression and clinicopathologic factors and prognosis. RESULTS:In 72 NSCLC patients, 50 (69%) samples were evaluated as having high GIRK1 gene expression, and 22 (31%) were evaluated as having low GIRK1 gene expression. GIRK1 gene expression was significantly associated with lymph node metastasis, stage (p = 0.0194 for lymph node metastasis; p = 0.0207 for stage). The overall and stage I survival rates for patients with high GIRK1 gene expressed tumors was significantly worse than for those individuals whose tumors had low GIRK1 expression (p = 0.0004 for the overall group; p = 0.0376 for stage I). CONCLUSIONS:These data indicate that GIRK1 may contribute to tumor progression and GIRK1 gene expression can serve as a useful prognostic marker in the overall and stage I NSCLCs. |
| 巻・号 | 4 |
| ページ | 79 |
| 公開日 | 2004-11-13 |
| DOI | 10.1186/1471-2407-4-79 |
| PII | 1471-2407-4-79 |
| PMID | 15541182 |
| PMC | PMC535568 |
| MeSH | Adenocarcinoma / genetics Adenocarcinoma / mortality Adenocarcinoma / pathology Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / mortality Carcinoma, Non-Small-Cell Lung / pathology Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / mortality Carcinoma, Squamous Cell / pathology Female G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Regulation, Neoplastic / genetics* Humans Lung Neoplasms / genetics* Lung Neoplasms / mortality Lung Neoplasms / pathology Lymph Nodes / pathology Lymphatic Metastasis / genetics Lymphatic Metastasis / pathology Male Middle Aged Neoplasm Staging / methods Neoplasm Staging / mortality Potassium Channels, Inwardly Rectifying / genetics* Receptors, Autocrine Motility Factor Receptors, Cytokine / genetics Reverse Transcriptase Polymerase Chain Reaction / methods Survival Analysis Ubiquitin-Protein Ligases |
| IF | 3.15 |
| 引用数 | 16 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | PC-14(RCB0446) |