論文 - 詳細
| RRC ID | 42274 |
|---|---|
| 著者 | Mushiake H, Tsunoda T, Nukatsuka M, Shimao K, Fukushima M, Tahara H. |
| タイトル | Dendritic cells might be one of key factors for eliciting antitumor effect by chemoimmunotherapy in vivo. |
| ジャーナル | Cancer Immunol Immunother |
| Abstract |
In this study, we demonstrated that chemoimmunotherapy using S-1, a novel oral fluoropyrimidine anticancer drug, combined with lentinan (LNT), a beta (1 --> 3) glucan, was effective in vivo, and we clarified the augmentation of the function of dendritic cells (DCs) in vivo and in vitro. The survival period of Colon-26-bearing mice treated with S-1 + LNT was significantly more prolonged than that of mice treated with S-1 alone (P < 0.05). On the other hand, LNT did not prolong the survival period when combined with S-1 in Colon-26-bearing athymic mice. The frequency of CD86+ DCs infiltrated into Colon-26 was increased in mice treated with S-1 + LNT, and splenic DCs harvested from mice treated with S-1 + LNT showed more potent T-cell proliferation activity than that of DCs from mice treated with S-1 alone (P < 0.05). Furthermore, the activity of cytotoxic T lymphocytes (CTLs) in splenocytes of S-1 + LNT-treated mice was specific and more potent than that of CTLs from mice treated with S-1 alone (P < 0.05). These results suggest that modulation of specific immunity with LNT has a significant role in enhanced antitumor effects through the modification of DC function. We demonstrated that DCs might play an important role in chemotherapy, and the combination therapy of S-1 and LNT presents a promising chemoimmunotherapy, which might lead to better survival for cancer patients. |
| 巻・号 | 54(2) |
| ページ | 120-8 |
| 公開日 | 2005-2-1 |
| DOI | 10.1007/s00262-004-0585-x |
| PMID | 15592717 |
| MeSH | Adenocarcinoma / immunology Adenocarcinoma / prevention & control Adenocarcinoma / therapy Animals Antineoplastic Combined Chemotherapy Protocols / immunology Antineoplastic Combined Chemotherapy Protocols / pharmacology* Colorectal Neoplasms / immunology Colorectal Neoplasms / prevention & control Colorectal Neoplasms / therapy Combined Modality Therapy Dendritic Cells / immunology Dendritic Cells / metabolism* Drug Combinations Fibrosarcoma / immunology Fibrosarcoma / prevention & control Fibrosarcoma / therapy Immunotherapy, Adoptive* Lentinan / administration & dosage Lung Neoplasms / immunology Lung Neoplasms / prevention & control Lung Neoplasms / therapy Lymphoma / immunology Lymphoma / prevention & control Lymphoma / therapy Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Neoplasms, Experimental / immunology* Neoplasms, Experimental / prevention & control Neoplasms, Experimental / therapy Oxonic Acid / administration & dosage Pyridines / administration & dosage Rats Rats, Inbred Strains Spleen / immunology Survival Rate T-Lymphocytes, Cytotoxic / metabolism Tegafur / administration & dosage |
| IF | 5.442 |
| 引用数 | 33 |
| WOS 分野 | IMMUNOLOGY ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | Meth-A(RCB0464) |