Reference - Detail
| RRC ID | 42288 |
|---|---|
| Author | Miyoshi N, Uchida K, Osawa T, Nakamura Y. |
| Title | Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes. |
| Journal | Biofactors |
| Abstract |
Naturally occurring isothiocyanates are effective chemoprotective agents against chemical carcinogenesis in experimental animals. In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)-induced cell cycle arrest and apoptosis. The exposure of HL-60 cells to BITC resulted in the inhibition of the G2/M progression that coincided with the apoptosis induction. We demonstrated that BITC significantly up-regulated expression of the G2/M cell cycle arrest-regulating genes including p21, GADD45, and 14-3-3sigma. Thus, these gathered data further supported that BITC has a potential to induce apoptosis selectively in the proliferating pre-cancerous cells through a cell cycle arrest-dependent mechanism. |
| Volume | 21(1-4) |
| Pages | 23-6 |
| Published | 2004-1-1 |
| DOI | 10.1002/biof.552210106 |
| PMID | 15630165 |
| MeSH | Anticarcinogenic Agents / pharmacology* Apoptosis / drug effects Cell Cycle / drug effects Cell Division / drug effects Cell Division / genetics* G2 Phase / drug effects G2 Phase / genetics* Gene Expression Regulation / drug effects* HL-60 Cells HeLa Cells Humans Isothiocyanates / pharmacology* Reverse Transcriptase Polymerase Chain Reaction |
| IF | 4.734 |
| Times Cited | 23 |
| WOS Category | ENDOCRINOLOGY & METABOLISM BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | |