Reference - Detail
| RRC ID | 42291 |
|---|---|
| Author | Feng Y, Matsuura N, Ubukata M. |
| Title | Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively. |
| Volume | 57(10) |
| Pages | 627-33 |
| Published | 2004-10-1 |
| DOI | 10.7164/antibiotics.57.627 |
| PMID | 15638322 |
| MeSH | Animals Carbazoles / chemistry Carbazoles / isolation & purification* Carbazoles / pharmacology Cell Differentiation / drug effects Glycine / analogs & derivatives* Indoles / chemistry Indoles / isolation & purification* Indoles / pharmacology Nerve Growth Factor / antagonists & inhibitors* Neurites / drug effects Neurites / physiology Rats Streptomyces / metabolism* Structure-Activity Relationship |
| IF | 2.668 |
| Times Cited | 10 |
| WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY PHARMACOLOGY & PHARMACY IMMUNOLOGY MICROBIOLOGY |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |