RRC ID |
42293
|
著者 |
Jin GZ, Quan HJ, Koyanagi J, Takeuchi K, Miura Y, Komada F, Saito S.
|
タイトル |
4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells.
|
ジャーナル |
Cancer Lett
|
Abstract |
The cytotoxic effects on HCT 116, Hep G2 and HCT 116/VCR 100-1-1 cell lines of synthetic 4'-O-alkylaloenins (2-17), 4'-O-benzylaloenin (18) and 4'-O-allylaloenin (19) were examined by MTT assay, and compared with that of aloenin (1) isolated from Aloe arborescens Mill. Var. natalensis Berger which showed no marked effect (IC50 value: > 100 microM). The cytotoxic effects of 4'-O-alkylaloenin sulfates (21-29) were also examined on the same cell lines. The introduction of a longer alkyl group at the O-4' position of 1 resulted in a higher cytotoxic action on HCT 116 and Hep G2 cells. Among 4'-O-alkylaloenins 2-17, 4'-O-tetradecylaloenin 14 was the most cytotoxic to both on HCT 116 cells (IC50 value: 5.3+/-2.3 microM) and Hep G2 cells (IC50 value: 4.0+/-0.6 microM). Also among 4'-O-alkylaloenin sulfates 21-29, 4'-O-dodecylaloenin sulfate 29 was the most cytotoxic to both on HCT 116 (IC50 value: 4.8+/-0.2 microM) and Hep G2 cells (IC50 value: 4.0+/-0.5 microM). 4'-O-Alkylaloenins 7-14 and 4'-O-alkylaloenin sulfates 24-29 were also cytotoxic to Hep G2 and HCT 116/VCR 100-1-1 cell lines, which overexpress P-glycoprotein, as well as HCT 116 cell lines which scarcely express it.
|
巻・号 |
218(1)
|
ページ |
15-20
|
公開日 |
2005-1-31
|
DOI |
10.1016/j.canlet.2004.07.025
|
PII |
S0304-3835(04)00576-2
|
PMID |
15639336
|
MeSH |
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Carcinoma, Hepatocellular / pathology
Colorectal Neoplasms
Coloring Agents / chemistry
Drug Resistance, Multiple*
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Glucosides / chemistry
Glucosides / pharmacology*
Humans
Liver Neoplasms / pathology
Sulfates
Tetrazolium Salts / chemistry
Thiazoles / chemistry
Tumor Cells, Cultured
|
IF |
7.36
|
引用数 |
10
|
WOS 分野
|
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
|