RRC ID 42300
Author Kawai K, Saijo K, Oikawa T, Ohno T, Akaza H.
Title Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression.
Journal Int J Urol
Abstract The unexplained regression of a metastasis of renal cell carcinoma (RCC) is rare phenomenon. While an immune mechanism has been proposed for spontaneous or unexplained regression of RCC, only limited data are available regarding immunological response. We report a case of a 62-year-old man with RCC whose paravertebral pleural tumor regressed after the withdrawal of interferon-alpha. In the present case, we demonstrate the enhancement of T cell proliferative response against autologous RCC cells secondary to the unexplained regression using the mixed-lymphocyte tumor culture. To our knowledge, the enhancement of an antitumor immunity secondary to an unexplained regression of RCC has not previously been reported.
Volume 11(12)
Pages 1130-2
Published 2004-12-1
DOI 10.1111/j.1442-2042.2004.00954.x
PMID 15663688
MeSH Carcinoma, Renal Cell / immunology* Carcinoma, Renal Cell / secondary* Cell Proliferation Humans Interferon-alpha / physiology Kidney Neoplasms / immunology* Kidney Neoplasms / pathology* Male Middle Aged Pleural Neoplasms / immunology* Pleural Neoplasms / secondary* Remission, Spontaneous T-Lymphocytes / physiology
IF 2.445
Times Cited 2
Human and Animal Cells