論文 - 詳細
| RRC ID | 42302 |
|---|---|
| 著者 | Kotake-Nara E, Terasaki M, Nagao A. |
| タイトル | Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Apoptosis induced by fucoxanthin in HL-60 cells was associated with a loss of mitochondrial membrane potential at an early stage, but not with an increase in reactive oxygen species. Fucoxanthin treatment caused cleavages of procaspase-3 and poly (ADP-ribose) polymerase without any effect on the protein level of Bcl-2, Bcl-X(L), or Bax. Apoptosis induction by fucoxanthin may be mediated via mitochondrial membrane permeabilization and caspase-3 activation. |
| 巻・号 | 69(1) |
| ページ | 224-7 |
| 公開日 | 2005-1-1 |
| DOI | 10.1271/bbb.69.224 |
| PII | JST.JSTAGE/bbb/69.224 |
| PMID | 15665492 |
| MeSH | Anticarcinogenic Agents / pharmacology* Apoptosis / drug effects* Caspase 3 Caspases / metabolism Cell Line, Tumor Humans Intracellular Membranes / drug effects Leukemia, Promyelocytic, Acute Mitochondria / drug effects Poly(ADP-ribose) Polymerases / metabolism Reactive Oxygen Species Xanthophylls / pharmacology* |
| IF | 1.516 |
| 引用数 | 66 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) HP50-2(RCB0768) HP100-1(RCB0769) |