| RRC ID |
42339
|
| 著者 |
Mao HQ, Shipanova-Kadiyala I, Zhao Z, Dang W, Brown A, Leong KW.
|
| タイトル |
Biodegradable poly(terephthalate-co-phosphate)s: synthesis, characterization and drug-release properties.
|
| ジャーナル |
J Biomater Sci Polym Ed
|
| Abstract |
To develop biodegradable polymers with favorable physicochemical and biological properties, we have synthesized a series of poly(terephthalate-co-phosphate)s using a two-step poly-condensation. The diol 1,4-bis(2-hydroxyethyl) terephthalate was first reacted with ethylphosphorodichloridate (EOP), and then chain-extended with terephthaloyl chloride (TC). Incorporation of phosphate into the poly(ethylene terephthalate) backbone rendered the co-polymers soluble in chloroform and biodegradable, lowered the Tg, decreased the crystallinity and increased the hydrophilicity. With an EOP/TC molar feed ratio of 80: 20, the polymer exhibited good film-forming property, yielding at 86.6 +/- 1.6% elongation with an elastic modulus of 13.76 +/- 2.66 MPa. This polymer showed a favorable toxicity profile in vitro and good tissue biocompatibility in the muscular tissue of mice. In vitro the polymer lost 21% of mass in 21 days, but only 20% for up to 4 months in vivo. It showed no deterioration of properties after sterilization by gamma-irradiation at 2.5 Mrad on solid CO2. Release of FITC-BSA from the microspheres was diffusion-controlled and exceeded 80% completion in two days. Release of the hydrophobic cyclosporine-A from microspheres was however much more sustained and near zero-ordered, discharging 60% in 70 days. A limited structure-property relationship has been established for this co-polymer series. The co-polymers became more hydrolytically labile as the phosphate component (EOP) was increased and the side chains were switched from the ethoxy to the methoxy structure. Converting the methoxy group to a sodium salt further increased the degradation rate significantly. The chain rigidity as reflected in the Tg values of the co-polymers decreased according to the following diol structure in the backbone: ethylene glycol > 2-methylpropylene diol > 2,2-dimethylpropylene diol. The wide range of physicochemical properties obtainable from this co-polymer series should help the design of degradable biomaterials for specific biomedical applications.
|
| 巻・号 |
16(2)
|
| ページ |
135-61
|
| 公開日 |
2005-1-1
|
| DOI |
10.1163/1568562053115426
|
| PMID |
15794482
|
| PMC |
PMC2376812
|
| MeSH |
Animals
Biocompatible Materials / chemical synthesis*
Biocompatible Materials / chemistry
Biocompatible Materials / toxicity
Biodegradation, Environmental
Cell Line
Humans
Microspheres
Organophosphates / chemistry*
Phthalic Acids / chemical synthesis*
Phthalic Acids / chemistry
Phthalic Acids / toxicity
Polymers / chemical synthesis*
Polymers / chemistry
Polymers / toxicity
Rats
Rats, Sprague-Dawley
Serum Albumin, Bovine / chemistry*
|
| IF |
2.69
|
| 引用数 |
16
|
|
WOS 分野
|
POLYMER SCIENCE
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
GT3TKB(RCB0885) |
