論文 - 詳細
| RRC ID | 42339 |
|---|---|
| 著者 | Mao HQ, Shipanova-Kadiyala I, Zhao Z, Dang W, Brown A, Leong KW. |
| タイトル | Biodegradable poly(terephthalate-co-phosphate)s: synthesis, characterization and drug-release properties. |
| ジャーナル | J Biomater Sci Polym Ed |
| Abstract |
To develop biodegradable polymers with favorable physicochemical and biological properties, we have synthesized a series of poly(terephthalate-co-phosphate)s using a two-step poly-condensation. The diol 1,4-bis(2-hydroxyethyl) terephthalate was first reacted with ethylphosphorodichloridate (EOP), and then chain-extended with terephthaloyl chloride (TC). Incorporation of phosphate into the poly(ethylene terephthalate) backbone rendered the co-polymers soluble in chloroform and biodegradable, lowered the Tg, decreased the crystallinity and increased the hydrophilicity. With an EOP/TC molar feed ratio of 80: 20, the polymer exhibited good film-forming property, yielding at 86.6 +/- 1.6% elongation with an elastic modulus of 13.76 +/- 2.66 MPa. This polymer showed a favorable toxicity profile in vitro and good tissue biocompatibility in the muscular tissue of mice. In vitro the polymer lost 21% of mass in 21 days, but only 20% for up to 4 months in vivo. It showed no deterioration of properties after sterilization by gamma-irradiation at 2.5 Mrad on solid CO2. Release of FITC-BSA from the microspheres was diffusion-controlled and exceeded 80% completion in two days. Release of the hydrophobic cyclosporine-A from microspheres was however much more sustained and near zero-ordered, discharging 60% in 70 days. A limited structure-property relationship has been established for this co-polymer series. The co-polymers became more hydrolytically labile as the phosphate component (EOP) was increased and the side chains were switched from the ethoxy to the methoxy structure. Converting the methoxy group to a sodium salt further increased the degradation rate significantly. The chain rigidity as reflected in the Tg values of the co-polymers decreased according to the following diol structure in the backbone: ethylene glycol > 2-methylpropylene diol > 2,2-dimethylpropylene diol. The wide range of physicochemical properties obtainable from this co-polymer series should help the design of degradable biomaterials for specific biomedical applications. |
| 巻・号 | 16(2) |
| ページ | 135-61 |
| 公開日 | 2005-1-1 |
| DOI | 10.1163/1568562053115426 |
| PMID | 15794482 |
| PMC | PMC2376812 |
| MeSH | Animals Biocompatible Materials / chemical synthesis* Biocompatible Materials / chemistry Biocompatible Materials / toxicity Biodegradation, Environmental Cell Line Humans Microspheres Organophosphates / chemistry* Phthalic Acids / chemical synthesis* Phthalic Acids / chemistry Phthalic Acids / toxicity Polymers / chemical synthesis* Polymers / chemistry Polymers / toxicity Rats Rats, Sprague-Dawley Serum Albumin, Bovine / chemistry* |
| IF | 2.69 |
| 引用数 | 16 |
| WOS 分野 | POLYMER SCIENCE ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | GT3TKB(RCB0885) |