論文 - 詳細
| RRC ID | 42342 |
|---|---|
| 著者 | Nakamura K, Konoha K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M. |
| タイトル | Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. |
| ジャーナル | In Vivo |
| Abstract |
We investigated the anti-metastatic effect of cordycepin (3'-deoxyadenosine) on a hematogenic metastatic mouse model which was intravenously injected with B16-BL6 melanoma cells. A 3-hour exposure to various concentrations of cordycepin (0.3, 1 and 3 microg/ml) dose-dependently reduced the number of nodules formed in lung at 15 days after the tumor injection. To elucidate the mechanism of this anti-metastatic effect, we examined the effect of cordycepin on the invasiveness of B16-BL6 cells using a chemo-invasion chamber in vitro. The B16-BL6 cells pretreated with cordycepin (3 microg/ml) for 3 hours showed a significant decrease in invasiveness. Under the same conditions, however, cordycepin did not influence the growth curve of B16-BL6 cells at concentrations up to 3 microg/ml. These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells. |
| 巻・号 | 19(1) |
| ページ | 137-41 |
| 公開日 | 2005-1-1 |
| PMID | 15796166 |
| MeSH | Animals Antineoplastic Agents / pharmacology* Deoxyadenosines / pharmacology* Disease Models, Animal* Dose-Response Relationship, Drug Female Injections, Intravenous Lung Neoplasms / prevention & control* Lung Neoplasms / secondary* Melanoma, Experimental / pathology Mice Mice, Inbred C57BL Neoplasm Invasiveness / prevention & control Neoplasm Metastasis / prevention & control* Neoplasm Transplantation Specific Pathogen-Free Organisms Time Factors Tumor Cells, Cultured |
| IF | 1.541 |
| 引用数 | 55 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH3T3-3 |