| RRC ID |
42342
|
| 著者 |
Nakamura K, Konoha K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M.
|
| タイトル |
Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice.
|
| ジャーナル |
In Vivo
|
| Abstract |
We investigated the anti-metastatic effect of cordycepin (3'-deoxyadenosine) on a hematogenic metastatic mouse model which was intravenously injected with B16-BL6 melanoma cells. A 3-hour exposure to various concentrations of cordycepin (0.3, 1 and 3 microg/ml) dose-dependently reduced the number of nodules formed in lung at 15 days after the tumor injection. To elucidate the mechanism of this anti-metastatic effect, we examined the effect of cordycepin on the invasiveness of B16-BL6 cells using a chemo-invasion chamber in vitro. The B16-BL6 cells pretreated with cordycepin (3 microg/ml) for 3 hours showed a significant decrease in invasiveness. Under the same conditions, however, cordycepin did not influence the growth curve of B16-BL6 cells at concentrations up to 3 microg/ml. These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells.
|
| 巻・号 |
19(1)
|
| ページ |
137-41
|
| 公開日 |
2005-1-1
|
| PMID |
15796166
|
| MeSH |
Animals
Antineoplastic Agents / pharmacology*
Deoxyadenosines / pharmacology*
Disease Models, Animal*
Dose-Response Relationship, Drug
Female
Injections, Intravenous
Lung Neoplasms / prevention & control*
Lung Neoplasms / secondary*
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness / prevention & control
Neoplasm Metastasis / prevention & control*
Neoplasm Transplantation
Specific Pathogen-Free Organisms
Time Factors
Tumor Cells, Cultured
|
| IF |
1.541
|
| 引用数 |
55
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| リソース情報 |
| ヒト・動物細胞 |
NIH3T3-3 |
