論文 - 詳細
| RRC ID | 42348 |
|---|---|
| 著者 | Muzandu K, El Bohi K, Shaban Z, Ishizuka M, Kazusaka A, Fujita S. |
| タイトル | Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage. |
| ジャーナル | Jpn J Vet Res |
| Abstract |
The consumption of fruits and vegetables is associated with a reduced risk of various ailments, including cancer and cardiovascular diseases. Carotenoids, such as lycopene and beta-carotene, are natural constituents of edible plants and may protect against disease. In this study, the influence of lycopene and beta-carotene on DNA damage caused by catechol-estrogens in vitro is examined. One possible mechanism by which catechol estrogens such as 4-hydroxyestradiol (4-OHE2) and 2-hydroxyestradiol, which cause DNA damage in naked plasmid DNA as well as in cells, contributing to the process of carcinogenesis, is through the generation of reactive oxygen species. It was found that both carotenoids at concentrations ranging from 0.25 to 10 microM significantly inhibit strand breakage induced by 4-OHE2/copper sulphate by up to approximately 90% in plasmid DNA with beta-carotene being slightly more effective. No prooxidant or cytotoxic effects were observed at the concentrations tested. These carotenoids had a similar, though reduced effect on DNA damage as measured by the comet assay, in Chinese hamster lung fibroblasts. The results obtained show that both lycopene and beta-carotene, most probably and mainly through their potent antioxidant properties, are able to inhibit catechol-estrogen-mediated DNA damage. |
| 巻・号 | 52(4) |
| ページ | 173-84 |
| 公開日 | 2005-2-1 |
| PMID | 15822859 |
| MeSH | Animals Antimutagenic Agents Antioxidants / pharmacology* Carotenoids / pharmacology* Cell Line Comet Assay Cricetinae Cricetulus DNA Damage / drug effects* Estradiol / analogs & derivatives* Estradiol / toxicity Estrogen Antagonists / pharmacology* Estrogens, Catechol Lycopene Oxidative Stress beta Carotene / pharmacology* |
| IF | 0.323 |
| 引用数 | 19 |
| WOS 分野 | VETERINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |