Reference - Detail
| RRC ID | 42381 |
|---|---|
| Author | Tian Y, Guo H, Han J, Guo D. |
| Title | Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus. |
| Journal | J Nat Prod |
| Abstract |
Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells). |
| Volume | 68(5) |
| Pages | 678-80 |
| Published | 2005-5-1 |
| DOI | 10.1021/np049688+ |
| PMID | 15921408 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / pharmacology Biotransformation Drug Screening Assays, Antitumor Molecular Structure Mucor / metabolism* Sapogenins / metabolism* Sapogenins / pharmacology Stereoisomerism Triterpenes / metabolism* Triterpenes / pharmacology |
| IF | 3.782 |
| Times Cited | 26 |
| WOS Category | PHARMACOLOGY & PHARMACY PLANT SCIENCES CHEMISTRY, MEDICINAL |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |